Ameliorative Effect of Vitamin E on Paraquat Induced Nephrotoxicity in Rat
- By Benjamin Nnamdi Okolonkwo, Ngozi Brisibe, Ibitoroko Maureen George-Opuda - 18 Feb 2023
- Current Research in Interdisciplinary Studies, Volume: 2, Issue: 2, Pages: 1 - 5
- Received: January 15, 2023; Accepted: February 10, 2023; Published: February 18, 2023
The kidney is a very vital organ required for excretion of metabolic waste products in the body and when the kidney is damaged, this function is compromised. Paraquat is a toxicant that is known to have toxic injuries in different organs. Therefore, the aim of this study was to uncover the treatment effect of vitamin E in paraquat inflicted kidney injury. The experimental animals (male rats) were 200 and they were classified into 4 groups designated as A, B, C and D. The A served as the control group, B, C and D were test groups classified based on dose of paraquat administered. A was not treated with paraquat, B, C and D were treated with 0.02g, 0.04g and 0.06g of paraquat respectively every two weeks for three months. Each group mentioned had subgroups designated “0” and “VE”; “0” subgroups were subgroups not treated with vitamin E while “VE” were subgroups treated with 500mg of vitamin E. Treatment of vitamin E occurred weekly for one month. Both vitamin E and paraquat treatments occurred orally. After treatment period rats were sacrificed and blood sample collected via cardiac puncture for urea and creatinine assay. The results showed that there was no significant difference in urea levels among paraquat alone treated groups but there was a significant increase in creatinine levels among paraquat alone treated groups. There was a significant decrease in creatinine level after vitamin E treatment. This study has shown that vitamin E is a therapeutic hope for paraquat inflicted nephrotoxicity in rats.
Keywords: kidney, paraquat, rat.