Assessing Short-Term Vitamin E and C Treatment Effect in Paraquat Liver Poisoning
- By Benjamin Nnamdi Okolonkwo, Ngozi Brisibe, Ibitoroko Maureen George-Opuda - 18 Feb 2023
- Journal of Applied Health Sciences and Medicine, Volume: 3, Issue: 2, Pages: 9 - 16
- Received: January 15, 2023; Accepted: February 13, 2023; Published: February 18, 2023
Paraquat has been considered as a toxicant in various countries, since it is not only intensely harmful but yet promptly accessible and generally cheap. Vitamin C and E are notable cancer prevention agents that respond rapidly to free radical and maximally forestall lipid peroxidation. The aim of this study was to evaluate the ameliorative impact of vitamin E and C in paraquat induced liver poisoning in rat. A total of 200 male wistar rats were obtained for the study. With 50 rats each, the rats were arranged into four grougs: A, B, C, and D. Each group was partitioned into two subgroups (0 and VEC), each with 25 rodents. The "A" group was not treated with paraquat, while the "B," "C," and "D" groups got 0.02g, 0.04g, and 0.06g of paraquat treatment respectively. All the "0" subgroups were those not treated with Vit E and C and all “VEC” subgroups were those treated with 500mg of vitamin E and 2000mg/dl of vitamin C. The paraquat treatment was administered once every 2 weeks for 3 months, followed by one month of week by week vitamin E and C treatment. Blood was drawn for SGPT, SGOT, ALP, and GGT testing. At p-value of 0.05, there was a significant increase in the activities of liver enzymes among the "A0", "B0", "C0", and "D0" groups. There was a significant decrease (P-value<0.05) in the activities of liver enzymes in “VEC” subgroups. This study uncovered that vitamin E and C combined treatment ameliorated the Paraquat induced liver injury in rats.
Keywords: paraquat, rats, vitamins, antioxidant, lipid peroxidation.