Research Article

Fusion and Bacterialcidal Activity of 7-bromo-2-(o-aminophenyl)- 3-amino-Quinazolin-4(3H)-one from 7-bromo,2-(o-aminophenyl)- 1,3-benzoxazin-4(3H)-one

Abstract

Background: Different types of Quinazolinones exhibit a wide spectrum of biological activities including anticancer, antimicrobial, anticonvulsant, antitubercular, anti-inflammatory, anlagesic, estrogenic and antiparkinsonism . Along 5-membered heterocycles thiazolidinone are found to be significant in their anticonvulsant and antimicrobial. Based on these findings the planned to synthesize the title compounds presuming that these chemical entities with thiazolidinone moiety in conjunction with Quinazolinone through imino bridge. Methods: The compound 2-(o-thiadiaminephenyl)-3-thiadiamine-7-bromo– quinazoline- 4(3H)-one (1), was produce when 2-(o-aminophenyl)-3-amino-6-bromo–Quinazolin-4(3H)- one (0.055 M) was dissolved in minimum amount of dil. HCl in a round bottom flask. Ammonium thiocyanate (0.11 M, 9.68 gm) was then added and the mixture refluxed for 7 hrs. A mixture of 2-(o thiadiaminephenyl)-3-thiadiamine-7-bromo–Quinazolin-4(3H)-one (0.037 M, 16.095 gm) and fused sodium acetate (0.074 M, 6.068 gm) was taken in absolute alcohol (300 ml) and refluxed for 10 hours to give 7-bromo-2-[o-imino-(4-thiazolidinone)- phenyl]-3-imino-(4 thiazolidinone)-Quinazolin-4(3H)-one (2). These Compounds were evaluated for their antibacterial activity (against some gram positive and gram negative microorganism) and antifungal activity (against Candida albicans). Study Design: This study was experimentally design and the antibacterial activity was evaluated against some microorganism, Staphylococcus aureus, Bacillus species, Aspergillus Species, Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumonia, and candida albicans. Result: The compounds exhibited significant antibacterial activity with a zone of inhibition in the range of 10 – 20 mm in comparison to control. Conclusions: From our findings, the compounds synthesized have higher antibacterial activities against Staphylococcus aureus, Aspergillus Species, as compared to Ciprofloxicin (CPX) and Ketonaxol (PEF) standard antibacterial drugs. 

Authors affiliation:

Osarodion Peter Osarumwense (ORCID): Department of Chemical Science, Ondo State University of Science and Technology, Okitipupa Ondo State, Nigeria
Tunmise Gideon Bamidele: Department of Chemical Science, Ondo State University of Science and Technology, Okitipupa Ondo State, Nigeria

How to Cite: O.P. Osarumwense and T.G. Bamidele. Fusion and Bacterialcidal Activity of 7-bromo-2-(o-aminophenyl)-3-amino-Quinazolin-4(3H)-one from 7-bromo,2-(oaminophenyl)- 1,3-benzoxazin-4(3H)-one. Healthcare Issues, 5(2):3–10, 2026. https://doi.org/10.58614/hi522