Review article

Sperm chromatin assay and its’ implication in male sub-fertily: review article

Abstract

Defect in sperm parameters decides the fertility potential of sub-fertile men and adversely correlates with pregnancy rate both in vivo and in vitro. Classical seminal fluid analysis is of a limited value in describing mans’ fertility status. This review is aimed to investigate the role of sperm chromatin assay and DNA damage in male sub-fertility. A clinical evidence has showed that sperms DNA damage has a negative impact on reproductive outcomes and the sperms of sub-fertile men substantially exhibit more DNA damage than those of fertile one in such a level that embryo development and pregnancy rate are impaired.