Research Article

Cytogenetic Analysis associated with Clinical Hypothyroid Iraqi patients: an in vitro study

Abstract

Hypothyroidism is a common endocrine disorder characterized by a deficiency of thyroid hormones (THs), commonly as a result of insufficient hormone production or less frequently due to insufficient hormone action in target tissues. It is most commonly seen in women between the ages of 30 and 50. The current study aims to investigate the cytogenetic indicators in hypothyroidism patients of different ages and compare them with a control group of healthy women . The current study was conducted on 20 Iraqi female patients with hypothyroidism and compared them with a healthy control group to assess chromosomal aberrations. The mitotic index and chromosomal aberration index were higher in hypothyroid patients than in healthy controls, with a significant difference at a probability level of less than 5%.